In this movie, Clooney's character, Matt, has to contend with feelings of both regret and betrayal towards someone who's alive, but doesn't talk back.
His wife is in a coma. When she wakes up he's ready to talk about their relationship. He'll ask forgiveness for crumbling of their marriage and the neglect of their children. He'll do better.
She's not going to wake up. And she was having an affair before she fell into the coma.
But the real question is how he'll deal with the anger, sadness and issue of forgiveness.
Good question. Good movie.